Endocrine Abstracts

Vitamin K is known as a critical cofactor in blood coagulation and bone homeostasis by helping the function of vitamin K-dependent gamma-carboxylase. We have recently shown that vitamin K2, one of the natural vitamin Ks, has a novel function to regulate the transcription of extracellular matrix-related genes in osteoblastic cells and increase collagen accumulation by activating the steroid and xenobiotic receptor, SXR. In the present study, we searched for novel vitamin K targ...